Systemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese Population

ID studio #: NCT05409833

condizione: Amiloidosi da transtiretina, sindrome del tunnel carpale

stato: reclutamento

Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis

intervento: Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD

risultati: https://clinicaltrials.gov/ct2/show/results/NCT05409833

ultimo aggiornamento: Dicembre 28, 2023

data d'inizio: 1 Giugno 2020

completamento previsto: 1 Giugno 2025

ultimo aggiornamento: Ottobre 19, 2023

taglia / iscrizione: 100

risultati primari:

• Frequency of transthyretin amyloidosis in synovial in patients with ≥60 years old
  Number of patients with transthyretin amyloidosis in synovial in relation to total number of patients submitted to hand surgery
• 24 mesi
  

risultati secondari:

• Association between synovial transthyretin amyloidosis with carpal tunnel syndrome
  24 mesi
• Association between idiopathic carpal tunnel syndrome with cardiac transthyretin amyloidosis
  24 mesi

criterio di inclusione:

criteri di esclusione: criteri:

. Diabetes mellitus, hypothyroidism, hemodialysis, rheumatoid arthritis, and other inflammatory arthropathies, multiple myeloma, gout, chondrocalcinosis, Colles fracture, space-occupying lesions, and infectious synovitis.

sponsor: Università di Porto

contatti: Elisabete Martins, MD, PhD, (+351) 965913480, [email protected]

investigatori: Elisabete Martins, MD, PhD,Faculty Of Medicine (FMUP)

sedi dei centri di prova:

• Portogallo
  Centro Ospedaliero Universitario São João
  Elisabete Martins, MD, PhD, (+351) 965913480, [email protected]
  
  
• Portogallo
  Facoltà di Medicina (FMUP)
  Janete Santos, PhD, (+351) 225 513 600, [email protected]